甲基化阳性的非特异性外周T细胞淋巴瘤1例报道
Wei Ren;Baorui Liu;Li Xie;Jing Yan;Weiwei Kong;Yang Yang;Lijing Zhu;Wenjing Hu;Xinyun Xu;Xiaoping Qian
【期刊名称】《中德临床肿瘤学杂志（英文版）》 【年(卷),期】2012(011)009
【摘 要】Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with no treatment consensus and poor prognosis. We herein described an extraordinary refractory case of PTCL-NOS with widely involvement of subcutaneous tissue, which showed an excellent response to Semustine personal- ized chemotherapy based on the detection finding of positive O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation. This is the first english report to indicate that single nitrosourea agent such as Semustine may have good efficacy and safety for widespread subcutaneous involvement of PTCL-NOS with positive MGMT promoter methylation.
【总页数】4页(P544-547)
【作 者】Wei Ren;Baorui Liu;Li Xie;Jing Yan;Weiwei Kong;Yang Yang;Lijing Zhu;Wenjing Hu;Xinyun Xu;Xiaoping Qian
【作者单位】Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008 China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008
China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008
China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008
China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008
China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008
China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008
China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008 China;Department of Pathology Drum Tower Hospital Nanjing 210008 China;Comprehensive Cancer Center of Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing 210008 China 【正文语种】中 文
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